Activation of I B Kinase and NF- B Is Essential for Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils

نویسندگان

  • Ayako Yanai
  • Shin Maeda
  • Wataru Shibata
  • Yohko Hikiba
  • Kei Sakamoto
  • Hayato Nakagawa
  • Tomoya Ohmae
  • Yoshihiro Hirata
  • Keiji Ogura
  • Susumu Muto
  • Akiko Itai
  • Masao Omata
چکیده

Activation of I B Kinase and NFB Is Essential for Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils Ayako Yanai, Shin Maeda,* Wataru Shibata, Yohko Hikiba, Kei Sakamoto, Hayato Nakagawa, Tomoya Ohmae, Yoshihiro Hirata, Keiji Ogura, Susumu Muto, Akiko Itai, and Masao Omata Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005, Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, and Institute of Medicinal Molecular Design, Inc., 5-24-5 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Traditional Thai Medicines inhibit Helicobacter pylori in vitro and in vivo: Support for ethnomedical use

In Thailand, traditional plant-based medicines have always been used to treat gastrointestinal ailments, including gastritis, peptic ulcer disease (PUD) and diarrhea. Since Helicobacter pylori (HP) is an etiological agent of PUD, we have used an ethnomedical approach for screening plant extracts as potential treatments for HP infections, including over 20 species from Thailand. International Me...

متن کامل

FR167653, a p38 mitogen-activated protein kinase inhibitor, prevents Helicobacter pylori-induced gastritis in Mongolian gerbils.

FR167653 was discovered as a cytokine production inhibitor, but its target molecule has remained unclear. We examined the effect of FR167653 on activities of purified protein kinases. FR167653 dose dependently inhibited p38alpha mitogen-activated protein kinase activity without affecting the activities of other kinases. FR167653 had no effect on cyclooxygenase (COX)-1 or COX-2 activities, where...

متن کامل

Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils.

Experimental infection with Helicobacter pylori in Mongolian gerbils results in chronic gastritis and gastric cancer. To investigate epithelial cell proliferation, apoptosis, and mucosal cytokine responses in gastritis, Mongolian gerbils were infected with the H pylori SS1 strain. At 4 weeks post-infection, gastritis was predominantly within the antrum, but extended to the corpus in approximate...

متن کامل

Helicobacter pylori and Gastric Carcinoma

A large amount of epidemiological evidence has accumulated indicating a significant relationship between Helicobacter pylori (Hp) infection and chronic gastritis [1,2], peptic ulcers [3], intestinal metaplasia [4,5], and adenocarcinoma [6–8] or lymphoma [9] development. In 1994, the World Health Organization/International Agency for Research on Cancer concluded that “Hp is a definite carcinogen...

متن کامل

Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil

Helicobacter pylori infection induces various gastroduodenal diseases. We examined the role of two genes, vacA and cagE, in the gastric pathogenesis induced by H. pylori using a long-term (62 wk) animal model. Reportedly, both genes are associated with the virulence of H. pylori: vacA encodes vacuolating cytotoxin, and cagE, with other genes in the cag pathogenicity islands, encodes a type IV s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008